Dissecting telomere maintenance mechanisms in pediatric glioblastoma
نویسندگان
چکیده
1 Research Group Genome Organization & Function, German Cancer Research Center (DKFZ) & BioQuant, 69120 Heidelberg, Germany 2 Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, 07747 Jena, and Research Group Network Modelling, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI), 07745 Jena, Germany 3 Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany 4 Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany 5 Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany 6 Unité Mixte de Recherche du Centre National de la Recherche Scientifique 8203 "laboratoire Vectorologie et Nouvelles Thérapeutiques Anticancéreuses", et Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France 7 Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany 8 Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany
منابع مشابه
Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas
High-grade astrocytoma of WHO grade 4 termed glioblastoma multiforme (GBM) is a common human brain tumor with poor patient outcome. Astrocytoma demonstrates two known telomere maintenance mechanisms (TMMs) based on telomerase activity (TA) and on alternative lengthening of telomeres (ALT). ALT is associated with lower tumor grades and better outcome. In contrast to ALT, regulation of TA in tumo...
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تاریخ انتشار 2017